Nuclear and cytoplasmic expressions of ERβ1 and ERβ2 are predictive of response to therapy and alters prognosis in familial breast cancers

M Yan; M Rayoo; EA Takano; SB Fox

Journal article

Nuclear and cytoplasmic expressions of ERβ1 and ERβ2 are predictive of response to therapy and alters prognosis in familial breast cancers

M Yan, M Rayoo, EA Takano, SB Fox

Breast Cancer Research and Treatment | Published : 2011

DOI: 10.1007/s10549-010-0941-9

Abstract

Estrogen receptor (ER) α has been studied extensively in familial breast cancers but there are limited data on ERβ and its isoforms. This is an important issue since many BRCA1-associated tumours are "triple negative" and are resistant to conventional and targeted therapies. We performed an immunohistochemical study of pan-ERβ, ERβ1 and ERβ2 in a cohort of 123 familial breast carcinomas (35 BRCA1, 33 BRCA2 and 55 BRCAX) using a cut-off for positivity at 20% (Shaaban et al. in Clin Cancer Res 14:5228-5235, 2008). BRCA1 cancers were more likely to be nuclear ERα negative and nuclear pan-ERβ positive (21/32, 66%) when compared with BRCA2 (2/29, 7%) and BRCAX cancers (11/49, 22%) (both P < 0.001..

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University of Melbourne Researchers

Stephen Fox Author

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Grants

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

We wish to thank Heather Thorne, Eveline Niedermayr, the kConFab research nurses and staff, the staff and of the Family Cancer Clinics, the Clinical Follow Up Study (funded by NHMRC Grants 145684, 288704 and 454508). kConFab is supported by grants from the National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC) and by the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. This study was partly funded by the Victorian Breast Cancer Research Consortium, the NHMRC, the Royal College of Pathologists of Australasia and the Victorian Cancer Biobank.